1. HPR retains the active functional group of retinoic acid and can bind directly to receptors without converting to retinoic acid, acting quickly. Compared to retinol and other ester derivatives, it has a smaller molecular weight, is more easily absorbed through the skin, and is more stable.

2. Among a series of vitamin A derivatives, HPR has the best stability within its category.

3. It is recommended to pre-dissolve HPR pure powder in oil esters before adding to formulations, or use the 10% DMI (dimethyl isosorbide) dissolved specification.

4. It is recommended for use in emulsified systems or all-oil systems, added below 45°C, with low-temperature homogenization and stirring.

5. The recommended formulation pH is 5.0–6.0.

6. It is advised to include antioxidants (such as vitamin E), chelating agents (like EDTA), and photoprotectants in the formula to stabilize HPR in the product. Vacuum-sealed bottles are preferable for the finished product.

7. For gentler effects, the formula can also include various soothing and anti-sensitivity ingredients with different mechanisms of action.

8. Both HPR raw materials and finished products containing HPR should use light-protective packaging and are recommended to be stored at low temperatures to minimize the impact of temperature on HPR content.